There is some evidence that it inhibits afferent nerve fibers in the bladder that are mechanosensitive. The drug has limited diagnostic uses.Īlthough this mechanism has not been substantiated, phenazopyridine is believed to exert an analgesic action locally on the urinary tract mucosa. In clinical and inpatient environments, phenazopyridine alleviates these same symptoms following endoscopic procedures, the passage of catheters, trauma, and surgery. Because of its analgesic properties, it should decrease the need for systemic analgesics and other medications. Phenazopyridine is compatible with concurrent antibiotic therapy, and its analgesic properties should improve the patient’s comfort until antibiotics can control the infection. It is FDA-approved and used in the outpatient setting to relieve the burning, urgency, frequency, and pain associated with lower UTIs. Currently, the drug is sold as a single-agent product and is classified as a urinary analgesic. Over the decades, the drug was marketed alone and combined with an antibiotic or other agents. Antibiotics, introduced in the late 1930s, provided a curative treatment for UTIs, and the use of phenazopyridine continued as an adjuvant. Phenazopyridine was widely prescribed to treat lower urinary tract infections (UTIs) under the false assumption that it was bactericidal. There was no regulatory requirement for pre-clinical studies to prove that medications were safe and effective. Phenazopyridine is an azo dye first synthesized in 1914 and adopted by the U.S. In this article, a UTI will refer to an infection of the lower urinary tract, the bladder (cystitis), and the urethra. This activity reviews the use, mechanism of action, adverse effects, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) of phenazopyridine pertinent for members of the healthcare team in the management of patients with UTI and related conditions. It is commonly used and available medication over the counter (OTC) and with a prescription. Phenazopyridine is used as an adjuvant medicine to treat the discomfort, urgency, and frequency associated with lower urinary tract infections (UTIs).
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